Sunday, October 3, 2010

Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility

Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility  

Here's a really good article from the Journal of The Endocrine Society.  It's quite heavy reading, but I linked it here for anyone interested in how cannabinoids interact with the reproductive system.

An excerpt:

 Mammalian reproduction is a complicated process designed to diversify and strengthen the genetic complement of the offspring and to safeguard regulatory systems at various steps for propagating procreation. An emerging concept in mammalian reproduction is the role of endocannabinoids, a group of endogenously produced lipid mediators, that bind to and activate cannabinoid receptors. Although adverse effects of cannabinoids on fertility have been implicated for years, the mechanisms by which they exert these effects were not clearly understood. With the identification of cannabinoid receptors, endocannabinoid ligands, their key synthetic and hydrolytic pathways, and the generation of mouse models missing cannabinoid receptors, a wealth of information on the significance of cannabinoid/endocannabinoid signaling in spermatogenesis, fertilization, preimplantation embryo development, implantation, and postimplantation embryonic growth has been generated...

Follow the link to read the rest...

59 comments:

  1. man I got a headache just from reading the excerpt haha don't think I'm brave enough for the whole article

    ReplyDelete
  2. Very tough stuff, think i'll leave this one.

    ReplyDelete
  3. Guess i learn something new everyday. Thanks !

    ReplyDelete
  4. wow... I didn't know that...
    learning IS fun!

    ReplyDelete
  5. Whoa! I'm always interestd in how cannabinoids interact with the reproductive system!

    ReplyDelete
  6. Complicated stuff right there!

    ReplyDelete
  7. heheh this put me on cloud nine, youve enhanced my next trip thanks ;p

    ReplyDelete
  8. ugh. i just found the full version, i better grab a snack...

    ReplyDelete
  9. um waht?? maybe you should summarize in layman's for us dumb folk.

    ReplyDelete
  10. Btw i recommend that you replace your bitvertiser with adbright. BV is shity idea you probably got from me

    ReplyDelete
  11. very interesting from my point of view...
    I'm always interested in how cannibalists interact with the reproductive system

    ReplyDelete
  12. Don't compare this to an old story come on bro.

    ReplyDelete
  13. Great post!
    looking forward to reading the next one

    ReplyDelete
  14. It is alway interesting to see what information you post next.

    ReplyDelete
  15. Endocrine society certifiably knows whats up

    ReplyDelete
  16. Regardless of the effect of canibinoids on the reproduction system I recommend using marijuana and appreciating the effects of cannibinoids

    ReplyDelete
  17. Those are a lot of big words. :|

    ReplyDelete
  18. You seem to be a die-hard cannibus/cannibanoid supporter. Where are you from?

    ReplyDelete
  19. mammalian reproduction is quite interesting!

    ReplyDelete
  20. Interesting. I'll have to give that article a read when I have some time.

    ReplyDelete
  21. that's pretty interesting, kind of headache inducing too.

    ReplyDelete
  22. Fertility and Cannabinoids? yum :3

    ReplyDelete
  23. really interesting article, i wish i knew more about biology lol

    ReplyDelete
  24. This was very interesting, but maybe you should point out that Cannabinoids are just a class of chemicals and not only to do with cannabis (although obviously Cannabis contains alot of them), I mean there's at least one cannabanoid in chocolate

    ReplyDelete
  25. very interesting!

    following & supporting.

    ReplyDelete
  26. Google doesn't have a tool to translate this into simple english.

    ReplyDelete
  27. Dude, that was a good ass read. Glad I'm following you, because I learned something today.

    ReplyDelete
  28. A little outside of my school of thought or specialization, but who doesn't like learning about something new?

    As a psych major, this does go more than a little over my head, though.

    ReplyDelete
  29. I'm looking forward to your next post!

    ReplyDelete
  30. I've always felt the effects of Cannabinoids are 'over-studied', if you will. Look hard enough into anything and you'll find stuff that seems related.
    Just use everything in moderation and there shouldn't be too many problems.

    ReplyDelete